CHM antibody (N-Term)

Catalog No. ABIN2792245

Product Details anti-CHM Antibody

Target: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Binding Specificity: N-Term

Reactivity: Human, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHM antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LHVDSRSYYG GNWASFSFSG LLSWLKEYQE NSDIVSDSPV WQDQILENEE

Predicted Reactivity: Horse: 80%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CHM. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHM

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 653 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CHM antibody (ABIN2792245)

Ishiguro, Yamamoto, Fujita, Akasu, Kobayashi, Moriya: "Effect of a clinical pathway after laparoscopic surgery for colorectal cancer." in: Hepato-gastroenterology, Vol. 55, Issue 85, pp. 1315-9, (2008) (PubMed).

Target Details for CHM

Target: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Alternative Name: CHM (CHM Products)

Synonyms: CHM antibody, REP1 antibody, DXS540 antibody, GGTA antibody, HSD-32 antibody, REP-1 antibody, TCD antibody, DKFZp459K2154 antibody, tcd antibody, ggta antibody, rep-1 antibody, dxs540 antibody, hsd-32 antibody, MGC68578 antibody, Rep-1 antibody, chm antibody, chm-a antibody, chm-b antibody, chml antibody, CHM, Rab escort protein 1 antibody, choroideremia (Rab escort protein 1) antibody, choroideremia (Rab escort protein 1) L homeolog antibody, choroidermia (RAB escort protein 1) antibody, choroideremia (Rab escort protein 1) S homeolog antibody, CHM antibody, chm antibody, chm.L antibody, Chm antibody, chm.S antibody

Background: CHM binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.The choroideremia gene encodes for a protein, the Rab escort protein-1 (REP1), which is involved in membrane trafficking.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DXS540, FLJ38564, GGTA, HSD-32, MGC102710, REP-1, TCD
Protein Interaction Partner: UBC, RAB1B, RAB32, RAB14, RAB3D, RAB7A, RAB18, RAB5B, RAB6A, RAB4A, RAB3B, RAB3A, RAB5A, RAB1A,
Protein Size: 653

Molecular Weight: 73 kDa

Gene ID: 1121

NCBI Accession: NM_000390, NP_000381

UniProt: P24386

Pathways: Sensory Perception of Sound