CHRNA9 antibody (N-Term)

Catalog No. ABIN2792251

Product Details anti-CHRNA9 Antibody

Target: CHRNA9 (Cholinergic Receptor, Nicotinic, alpha 9 (Neuronal) (CHRNA9))

Binding Specificity: N-Term

Reactivity: Mouse, Dog, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA9 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MNWSHSCISF CWIYFAASRL RAAETADGKY AQKLFNDLFE DYSNALRPVE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Mouse: 93%, Rabbit: 100%, Zebrafish: 80%

Characteristics: This is a rabbit polyclonal antibody against CHRNA9. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHRNA9

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 479 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CHRNA9 antibody (ABIN2792251)

Guha, Bandyopadhyaya, Polumuri, Chumsri, Gade, Kalvakolanu, Ahmed et al.: "Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic ..." in: Breast cancer research and treatment, Vol. 145, Issue 1, pp. 5-22, (2014) (PubMed).

Target Details for CHRNA9

Target: CHRNA9 (Cholinergic Receptor, Nicotinic, alpha 9 (Neuronal) (CHRNA9))

Alternative Name: CHRNA9 (CHRNA9 Products)

Synonyms: HSA243342 antibody, NACHRA9 antibody, 2410015I05Rik antibody, Acra9 antibody, EG666827 antibody, Gm8311 antibody, cholinergic receptor nicotinic alpha 9 subunit antibody, cholinergic receptor, nicotinic, alpha polypeptide 9 antibody, CHRNA9 antibody, Chrna9 antibody

Background: CHRNA9 is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor superfamily. CHRNA9 is a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. It is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea.This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.
Alias Symbols: NACHRA9, HSA243342
Protein Interaction Partner: UBC, Rapsn,
Protein Size: 479

Molecular Weight: 55 kDa

Gene ID: 55584

NCBI Accession: NM_017581, NP_060051

UniProt: Q9UGM1

Pathways: Sensory Perception of Sound