STX1A antibody (N-Term)

Catalog No. ABIN2792295

Product Details anti-STX1A Antibody

Target: STX1A (Syntaxin 1A (Brain) (STX1A))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STX1A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KDRTQELRTA KDSDDDDDVA VTVDRDRFMD EFFEQVEEIR GFIDKIAENV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against STX1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STX1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 288 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for STX1A

Target: STX1A (Syntaxin 1A (Brain) (STX1A))

Alternative Name: STX1A (STX1A Products)

Synonyms: HPC-1 antibody, P35-1 antibody, STX1 antibody, SYN1A antibody, STX1A antibody, hpc-1 antibody, p35-1 antibody, stx1 antibody, sx1a antibody, syntaxin1a antibody, CG10716 antibody, CG18615 antibody, CG31136 antibody, CG5448 antibody, CT30033 antibody, Dm Syx1 antibody, DmSyx1A antibody, Dmel\\CG31136 antibody, SYX1A antibody, Syt1A antibody, Syx antibody, Syx-1A antibody, Syx1 antibody, Syx1a antibody, SyxA antibody, anon-EST:Gibbs4 antibody, anon-WO02059370.54 antibody, dSyx1 antibody, l(3)06737 antibody, synt antibody, syt-1A antibody, syx antibody, syx-1 antibody, syx-1A antibody, syx1 antibody, syx1A antibody, syntaxin 1A antibody, syntaxin 1A (brain) antibody, Syntaxin 1A antibody, syntaxin-1A antibody, STX1A antibody, Stx1a antibody, stx1a antibody, Syx1A antibody, EDI_005240 antibody, Tsp_07354 antibody

Background: Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis. Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1253 BC064644.1 1-1253 1254-2117 BC000444.2 1209-2072
Alias Symbols: HPC-1, STX1, p35-1, P35-1, SYN1A
Protein Interaction Partner: STXBP1, SUMO1P1, TXLNA, TXLNB, NAPB, VAMP5, SNAP29, VAPB, SNAP23, STX1A, PSMA3, KCNB1, Htt, SNAP25, SLC6A3, SLC6A2, PPP1CA, pnut, Sep1, SNPH, TRDMT1, CCSER2, VPS11, SYT7, VPS18, RIMS1, CPLX1, SLC6A5, STXBP5, SYTL4, STXBP6, UNC13B, STX8, RAB27A, NAPA, VAMP
Protein Size: 288

Molecular Weight: 33 kDa

Gene ID: 6804

NCBI Accession: NM_004603, NP_004594

UniProt: Q16623

Pathways: Peptide Hormone Metabolism, Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport