ETV6 antibody (C-Term)

Catalog No. ABIN2792592

Product Details anti-ETV6 Antibody

Target: ETV6 (Ets Variant 6 (ETV6))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ETV6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: VSVSPPEEHA MPIGRIADCR LLWDYVYQLL SDSRYENFIR WEDKESKIFR

Cross-Reactivity: Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against ETV6. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ETV6

Application Details

Application Notes: WB Suggested Anti-ETV6 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 452 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ETV6

Target: ETV6 (Ets Variant 6 (ETV6))

Alternative Name: ETV6 / TEL1 (ETV6 Products)

Synonyms: etv-6 antibody, tel antibody, tel/abl antibody, AW123102 antibody, AW557856 antibody, Tel antibody, TEL antibody, id:ibd2308 antibody, TEL/ABL antibody, cmlc2 antibody, mylc2a antibody, zgc:92755 antibody, ETS variant 6 antibody, ets variant 6 antibody, myosin, light chain 7, regulatory antibody, etv6 antibody, Etv6 antibody, ETV6 antibody, myl7 antibody

Background: ETV6 (ETS-related protein Tel1, ETS translocation variant 6 , Tel) is an ETS family transcription factor. This protein contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TEL, TEL/ABL
Protein Interaction Partner: AP1M1, WDYHV1, UBC, SUMO1, NEDD8, ETV6, SUMO2, PIN1, HDAC6, SOX2, TRAF3, SOCS3, SOCS1, PDGFRB, ELAVL1, UBE2I, NCOR1, SIN3A, HDAC3, L3MBTL1, SMURF1, HDAC9, KAT5, FLI1, IRF8, SKP1, FBXL6, GAB2, GRB2, CRKL, ACTA1,
Protein Size: 452

Molecular Weight: 53 kDa

Gene ID: 2120

NCBI Accession: NM_001987, NP_001978

UniProt: P41212