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NR2C1 antibody (C-Term)

NR2C1 Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Guinea Pig, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792596
  • Target See all NR2C1 Antibodies
    NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))
    Binding Specificity
    • 13
    • 11
    • 10
    • 9
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 65
    • 16
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Guinea Pig, Pig
    Host
    • 58
    • 8
    Rabbit
    Clonality
    • 62
    • 4
    Polyclonal
    Conjugate
    • 39
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NR2C1 antibody is un-conjugated
    Application
    • 57
    • 30
    • 9
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    QEKAYVEFQD YITKTYPDDT YRLSRLLLRL PALRLMNATI TEELFFKGLI
    Cross-Reactivity
    Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 92%
    Characteristics
    This is a rabbit polyclonal antibody against NR2C1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human NR2C1
    Top Product
    Discover our top product NR2C1 Primary Antibody
  • Application Notes
    WB Suggested Anti-NR2C1 Antibody Titration: 2.5 µg/mL
    ELISA Titer: 1:312500
    Positive Control: HCT15 cell lysate.
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 603 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))
    Alternative Name
    NR2C1 (NR2C1 Products)
    Synonyms
    TR2 antibody, NR2C1 antibody, dor2 antibody, tr2-11 antibody, xDOR2 antibody, DKFZp468M0512 antibody, si:dkey-183c16.2 antibody, zgc:110672 antibody, 4831444H07Rik antibody, 80.3 antibody, Eenr antibody, Tr2-11 antibody, Tr2 antibody, Psg4 antibody, TR2-11 antibody, PSG9 antibody, nr2c1 antibody, nuclear receptor subfamily 2 group C member 1 antibody, nuclear receptor subfamily 2 group C member 1 S homeolog antibody, nuclear receptor subfamily 2, group C, member 1 antibody, pregnancy specific beta-1-glycoprotein 4 antibody, nuclear receptor subfamily 2 group C member 1 L homeolog antibody, NR2C1 antibody, nr2c1.S antibody, nr2c1 antibody, Nr2c1 antibody, PSG4 antibody, nr2c1.L antibody
    Background
    The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites
    Alias Symbols: TR2
    Protein Interaction Partner: PSPC1, MBD3, SIN3A, RCOR1, KDM1A, POLD3, TRIM28, RBM39, MTA2, MTA1, HDAC3, NR2C2, SMARCA4, SFPQ, RBBP7, RBBP4, NONO, HDAC2, HDAC1, HCFC1, DNMT1, CHD4, NUDT3, UBC, PML, HDAC4, NRIP1, AR, ESR1,
    Protein Size: 603
    Molecular Weight
    67 kDa
    Gene ID
    7181
    NCBI Accession
    NM_003297, NP_003288
    UniProt
    Q15625
    Pathways
    Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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