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Caveolin-1 antibody (N-Term)

CAV1 Reactivity: Human, Rat, Mouse, Dog, Pig, Cow, Rabbit, Sheep, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792696
  • Target See all Caveolin-1 (CAV1) Antibodies
    Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))
    Binding Specificity
    • 15
    • 14
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 107
    • 63
    • 49
    • 10
    • 9
    • 8
    • 8
    • 8
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog, Pig, Cow, Rabbit, Sheep, Horse
    Host
    • 98
    • 12
    • 6
    • 2
    Rabbit
    Clonality
    • 93
    • 25
    Polyclonal
    Conjugate
    • 82
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Caveolin-1 antibody is un-conjugated
    Application
    • 92
    • 38
    • 27
    • 27
    • 26
    • 17
    • 16
    • 16
    • 11
    • 11
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    SGGKYVDSEG HLYTVPIREQ GNIYKPNNKA MADELSEKQV YDAHTKEIDL
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Predicted Reactivity
    Cow: 80%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 80%, Rabbit: 86%, Rat: 86%, Sheep: 80%
    Characteristics
    This is a rabbit polyclonal antibody against CAV1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human CAV1
    Top Product
    Discover our top product CAV1 Primary Antibody
  • Application Notes
    WB Suggested Anti-CAV1 Antibody Titration: 0.2-1 µg/mL
    ELISA Titer: 1:62500
    Positive Control: Human Liver.
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 178 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))
    Alternative Name
    Caveolin-1 (CAV1 Products)
    Synonyms
    fc07c04 antibody, wu:fc07c04 antibody, Cav-1 antibody, bscl3 antibody, cav1 antibody, cav1a antibody, cgl3 antibody, vip21 antibody, cav1b antibody, caveolin-1 antibody, cav antibody, mstp085 antibody, Caveolin-1 antibody, CAV1 antibody, cav-1 antibody, Cav antibody, caveolin 1 antibody, BSCL3 antibody, CGL3 antibody, MSTP085 antibody, PPH3 antibody, VIP21 antibody, caveolin 1 antibody, caveolin 1 L homeolog antibody, caveolin 1 S homeolog antibody, caveolin 1, caveolae protein antibody, caveolin 1, caveolae protein, 22kDa antibody, Caveolin antibody, cav1 antibody, cav1.L antibody, cav1.S antibody, CAV1 antibody, Cav1 antibody, cav-1 antibody
    Background
    The scaffolding protein CAV1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: CAV, MSTP085, VIP21, CGL3, BSCL3
    Protein Interaction Partner: TFRC, ABCC1, UBC, RPA3, ATG5, ATG12, RPA2, RPA1, PTGIS, EGFR, VCP, UFD1L, PTGS2, PTGS1, ESR1, DERL1, VIMP, ATP4A, CAV2, GLIPR2, KDR, PROCR, F2R, BID, NOS3, HSP90AA1, FAS, ACTB, MALL, NF1, LRP6, KCNMA1, BMPR2, BMPR1A, AXIN1, PPP2CA, MCL1, ITPR3, ID1, TENC1
    Protein Size: 178
    Molecular Weight
    20 kDa
    Gene ID
    857
    NCBI Accession
    NM_001753, NP_001744
    UniProt
    Q03135
    Pathways
    Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals
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