Thrombomodulin antibody

Catalog No. ABIN1944809

Product Details anti-Thrombomodulin Antibody

Target: Thrombomodulin (THBD)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thrombomodulin antibody is un-conjugated

Application: Western Blotting (WB)

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-Thrombomodulin antibody (ABIN1944809)

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Shirai, Shiojiri, Ito, Yamamoto, Kusumoto, Deyashiki, Maruyama, Suzuki: "Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C." in: Journal of biochemistry, Vol. 103, Issue 2, pp. 281-5, (1988) (PubMed).

Suzuki, Kusumoto, Deyashiki, Nishioka, Maruyama, Zushi, Kawahara, Honda, Yamamoto, Horiguchi: "Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation." in: The EMBO journal, Vol. 6, Issue 7, pp. 1891-7, (1987) (PubMed).

Jackman, Beeler, Fritze, Soff, Rosenberg: "Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6425-9, (1987) (PubMed).

Wen, Dittman, Ye, Deaven, Majerus, Sadler: "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene." in: Biochemistry, Vol. 26, Issue 14, pp. 4350-7, (1987) (PubMed).

Target Details for Thrombomodulin

Target: Thrombomodulin (THBD)

Alternative Name: THBD (THBD Products)

Synonyms: AHUS6 antibody, BDCA3 antibody, CD141 antibody, THPH12 antibody, THRM antibody, TM antibody, AI385582 antibody, THBD antibody, HAST antibody, HAST3 antibody, M-PST antibody, ST1A3/ST1A4 antibody, ST1A5 antibody, STM antibody, TL-PST antibody, thrombomodulin antibody, sulfotransferase family 1A member 3 antibody, THBD antibody, Thbd antibody, SULT1A3 antibody

Background: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Molecular Weight: 60329 Da

Gene ID: 7056

UniProt: P07204