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GPBAR1 antibody (Alexa Fluor 594)

GPBAR1 Reactivity: Human WB, IF (p) Host: Rabbit Polyclonal Alexa Fluor 594
Catalog No. ABIN2808674
  • Target See all GPBAR1 Antibodies
    GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
    Reactivity
    • 42
    • 12
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 41
    • 2
    Rabbit
    Clonality
    • 41
    • 2
    Polyclonal
    Conjugate
    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPBAR1 antibody is conjugated to Alexa Fluor 594
    Application
    • 24
    • 12
    • 8
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GPBAR1
    Isotype
    IgG
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    Discover our top product GPBAR1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
    Alternative Name
    GPCR TGR5/GPBAR1 (GPBAR1 Products)
    Synonyms
    BG37 antibody, GPCR19 antibody, GPR131 antibody, M-BAR antibody, TGR5 antibody, Tgr5 antibody, MGC84403 antibody, GPBAR1 antibody, Gpbar1 antibody, GPCR antibody, G protein-coupled bile acid receptor 1 antibody, G protein-coupled bile acid receptor 1 S homeolog antibody, GPBAR1 antibody, Gpbar1 antibody, gpbar1.S antibody
    Background

    Synonyms: BG 37, BG37, G protein coupled bile acid receptor 1, G protein coupled bile acid receptor BG 37, G protein coupled bile acid receptor BG37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR_HUMAN, GPBAR1, GPCR 19, GPCR, GPCR19, GPR 131, GPR131, hBG 37, hBG37, hGPCR 19, hGPCR19, M BAR, M-BAR, Membrane bile acid receptor, Membrane type receptor for bile acids, Membrane-type receptor for bile acids, MGC40597, TGR 5, TGR5.

    Background: The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

    Gene ID
    151306
    Pathways
    WNT Signaling, Hormone Transport, Sensory Perception of Sound
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