SLITRK5 antibody (AA 301-400) (Alexa Fluor 594)

Catalog No. ABIN2808963

Product Details anti-SLITRK5 Antibody (Alexa Fluor 594)

Target: SLITRK5 (SLIT and NTRK-Like Family, Member 5 (SLITRK5))

Binding Specificity: AA 301-400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLITRK5 antibody is conjugated to Alexa Fluor 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLITRK5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SLITRK5

Target: SLITRK5 (SLIT and NTRK-Like Family, Member 5 (SLITRK5))

Alternative Name: SLITRK5 (SLITRK5 Products)

Synonyms: SLITRK5 antibody, LRRC11 antibody, bA364G4.2 antibody, 2610019D03Rik antibody, SLIT and NTRK like family member 5 antibody, SLIT and NTRK-like family, member 5 antibody, SLITRK5 antibody, slitrk5 antibody, Slitrk5 antibody

Background:

Synonyms: bA364G4.2; KIAA0918; Leucine rich repeat containing 11; Leucine rich repeat containing protein 11; LRRC 11; LRRC11; SLIT and NTRK like family member 5; SLIT and NTRK like protein 5; Slit and trk like gene 5; SLITRK 5; SLIK5_HUMAN.

Background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. SLITRK5 (SLIT and NTRK-like family, member 5), also known as LRRC11 (leucine-rich repeat-containing protein 11), is a 958 amino acid single-pass type I membrane protein that contains 16 LRR repeats and belongs to the SLITRK family. Expressed at high levels in the cerebral cortex, but also present in areas of the spinal cord and medulla, SLITRK5 functions to suppress neurite outgrowth, thereby playing a regulatory role in neuronal function. The gene encoding SLITRK5 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.