ANO3 antibody (AA 801-900) (Alexa Fluor 594)

Catalog No. ABIN2809005

Product Details anti-ANO3 Antibody (Alexa Fluor 594)

Target: ANO3 (Anoctamin 3 (ANO3))

Binding Specificity: AA 801-900

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANO3 antibody is conjugated to Alexa Fluor 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TMEM16C/Anoctamin 3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ANO3

Target: ANO3 (Anoctamin 3 (ANO3))

Alternative Name: TMEM16C/Anoctamin 3 (ANO3 Products)

Synonyms: TMEM16C antibody, anoctamin-3 antibody, C11orf25 antibody, DYT23 antibody, DYT24 antibody, AI838058 antibody, B230324K02Rik antibody, Tmem16c antibody, anoctamin 3 antibody, anoctamin-3 antibody, ANO3 antibody, LOC100453980 antibody, ano3 antibody, Ano3 antibody

Background:

Synonyms: ANO3, C11orf25, GENX 3947, TMEM16C, Transmembrane protein 16C eight membrane spanning domains, Transmembrane protein 16C, ANO3_HUMAN.

Background: TMEM16C is a 981 amino acid multi-pass membrane protein that is encoded by a gene which maps to chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4 % of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.

Gene ID: 63982