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DFFB antibody (AA 251-338) (Alexa Fluor 594)

DFFB Reactivity: Mouse IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 594
Catalog No. ABIN2812360
  • Target See all DFFB Antibodies
    DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
    Binding Specificity
    • 15
    • 14
    • 14
    • 10
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-338
    Reactivity
    • 56
    • 44
    • 24
    Mouse
    Host
    • 72
    • 4
    Rabbit
    Clonality
    • 73
    • 3
    Polyclonal
    Conjugate
    • 35
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This DFFB antibody is conjugated to Alexa Fluor 594
    Application
    • 58
    • 29
    • 25
    • 25
    • 18
    • 14
    • 11
    • 10
    • 6
    • 4
    • 3
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Dog,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DFFB
    Isotype
    IgG
    Top Product
    Discover our top product DFFB Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
    Alternative Name
    DFFB (DFFB Products)
    Synonyms
    CAD antibody, CPAN antibody, DFF-40 antibody, DFF2 antibody, DFF40 antibody, LOC100223514 antibody, 40kDa antibody, 5730477D02Rik antibody, Didff antibody, Cad antibody, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase antibody, DNA fragmentation factor subunit beta antibody, DNA fragmentation factor, beta polypeptide (caspase-activated DNase) antibody, DNA fragmentation factor, beta subunit antibody, CAD antibody, DFFB antibody, dffb antibody, LOC100223514 antibody, Dffb antibody
    Background

    Synonyms: CAD, Caldesmon, Caspase activated deoxyribonuclease, Caspase activated DNase, Caspase activated nuclease, CDM, CPAN, Deoxyribonuclease III, caspase activated, DFF 40, DFF2, DFF40, Didff, DNA fragmentation factor 40 kDa subunit, DNA fragmentation factor subunit beta, DNA fragmentation factor, 40 Da, beta polypeptide caspase activated DNase, DNA fragmentation factor, 40 kD beta subunit, DNA fragmentation factor, 40 kD, beta polypeptide, DNA fragmentation factor, 40 kDa, beta polypeptide caspase activated DNase, DNA fragmentation factor, 40 kDa, beta polypeptide caspase-activated DNase, DNAation factor, beta subunit, DFFB_HUMAN.

    Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].

    Gene ID
    1677
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis
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