Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) antibody (APC)

Details for Product No. ABIN282659
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Antigen
Synonyms AI449405, Cd11c, Cr4, N418, Itgax, RGD1561123, CD11C, SLEB6
Reactivity
Mouse (Murine)
(352), (223), (78), (12), (12), (11), (4), (2), (1)
Host
Armenian Hamster
(318), (125), (91), (50), (6), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
APC
(76), (64), (61), (32), (16), (15), (13), (11), (11), (9), (8), (6), (6), (6), (6), (6), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Flow Cytometry (FACS)
(465), (87), (79), (76), (73), (49), (40), (33), (20), (10), (10), (10), (10), (7), (7), (6), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Clone N418
Isotype IgG
Specificity The N418 monoclonal antibody reacts with mouse CD11c, the integrin alphaX.
Characteristics The N418 monoclonal antibody reacts with mouse CD11c, the integrin αX. CD11c non-covalently associates with β2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.
Synonyms: Synonyms: Integrin alpha X, Integrin aX, ITGAX, p150/95, leu M5 alpha
Alternative Name CD11c (ITGAX Antibody Abstract)
Background CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some, Mouse
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Application Notes Applications reported: The N418 antibody has been reported for use in flow cytometric analysis.

Applications tested: The N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Comment

Excitation/Emission wavelength: 650 nm/660 nm

Restrictions For Research Use only
Concentration 0.2 mg/mL
Buffer aqueous buffer, 0.09 % sodium azide, may contain carrier protein/stabilizer
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze. Light sensitive material.
Storage 4 °C
Supplier Images
anti-Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) antibody (APC) Staining of C57Bl/6 splenocytes with PE anti-human/mouse CD45R/B220 (RA3-6B2)(cat.ABI...
anti-Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) antibody (APC) (2) anti-Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) antibody (APC) (Image 2)
Background publications Kaplan, Li, Jenison et al.: "Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells." in: The Journal of experimental medicine, Vol. 204, Issue 11, pp. 2545-52, 2007 (PubMed).

Validation Images
Catalog No. ABIN282659
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