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NCAPH2 antibody (N-Term)

NCAPH2 Reactivity: Human WB Host: Rabbit Polyclonal RB9657 unconjugated
Catalog No. ABIN2837875
  • Target See all NCAPH2 Antibodies
    NCAPH2 (Non-SMC Condensin II Complex, Subunit H2 (NCAPH2))
    Binding Specificity
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 198-227, N-Term
    Reactivity
    • 17
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 16
    • 1
    Rabbit
    Clonality
    • 16
    • 1
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    This NCAPH2 antibody is un-conjugated
    Application
    • 15
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This NCAPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the N-terminal region of human NCAPH2.
    Clone
    RB9657
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Lai, Wong, Lee, Li: "Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death." in: Cell death and differentiation, Vol. 18, Issue 6, pp. 996-1004, (2011) (PubMed).

    Lisková, Susor, Pivonková, Sasková, Karabínová, Kubelka: "Detection of condensin I and II in maturing pig oocytes." in: Reproduction, fertility, and development, Vol. 22, Issue 4, pp. 644-52, (2010) (PubMed).

  • Target
    NCAPH2 (Non-SMC Condensin II Complex, Subunit H2 (NCAPH2))
    Alternative Name
    NCAPH2 (NCAPH2 Products)
    Synonyms
    MGC81656 antibody, CAPH2 antibody, si:dkey-202b22.2 antibody, non-SMC condensin II complex subunit H2 antibody, non-SMC condensin II complex subunit H2 L homeolog antibody, non-SMC condensin II complex, subunit H2 antibody, NCAPH2 antibody, ncaph2.L antibody, ncaph2 antibody, Ncaph2 antibody
    Background
    Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.
    Molecular Weight
    68227
    Gene ID
    29781
    NCBI Accession
    NP_001171940, NP_055366, NP_689512
    UniProt
    Q6IBW4
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