ARFGAP1 antibody (C-Term)

Catalog No. ABIN2839226

Product Details anti-ARFGAP1 Antibody

Target: ARFGAP1 (ADP-Ribosylation Factor GTPase Activating Protein 1 (ARFGAP1))

Binding Specificity: AA 377-406, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARFGAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ARFGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-406 amino acids from the C-terminal region of human ARFGAP1.

Clone: RB4855

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:8000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ARFGAP1 antibody (ABIN2839226)

Nishimura, Uchida, Yachi, Kudlyk, Lupashin, Inoue, Taguchi, Arai: "Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs." in: Molecular biology of the cell, Vol. 24, Issue 22, pp. 3534-44, (2013) (PubMed).

Zhang, Major, Takanashi, Camp, Nishiya, Peters, Ginsberg, Jian, Randazzo, Schultz, Moon, Ding: "Small-molecule synergist of the Wnt/beta-catenin signaling pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 18, pp. 7444-8, (2007) (PubMed).

Target Details for ARFGAP1

Target: ARFGAP1 (ADP-Ribosylation Factor GTPase Activating Protein 1 (ARFGAP1))

Alternative Name: ARFGAP1 (ARFGAP1 Products)

Synonyms: ARF1GAP antibody, HRIHFB2281 antibody, AI115377 antibody, Arf1gap antibody, Arf GAP1 antibody, arf1gap antibody, atfb1 antibody, atfb3 antibody, jlns1 antibody, k(v)7.1 antibody, kcna8 antibody, kcna9 antibody, kv1.9 antibody, kv7.1 antibody, kvlqt1 antibody, lqt antibody, lqt1 antibody, rws antibody, sqt2 antibody, wrs antibody, ARFGAP3 antibody, ADP ribosylation factor GTPase activating protein 1 antibody, ADP-ribosylation factor GTPase activating protein 1 antibody, ADP ribosylation factor GTPase activating protein 1 S homeolog antibody, putative ADP-ribosylation factor GTPase activating protein 1 antibody, ATP-dependent RNA helicase DBP9 antibody, ARFGAP1 antibody, Arfgap1 antibody, arfgap1.S antibody, Tb11.01.6060 antibody, arfgap1 antibody, LMJF_32_1230 antibody, MGYG_02419 antibody

Background: ARFGAP1 is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine.

Molecular Weight: 44668

Gene ID: 55738

NCBI Accession: NP_001268411, NP_001268412, NP_001268413, NP_060679, NP_783202

UniProt: Q8N6T3

Pathways: p53 Signaling, ER-Nucleus Signaling, Unfolded Protein Response