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CDC25A antibody (pThr507)

CDC25A Reactivity: Human WB, IHC (p), IF Host: Rabbit Polyclonal RB7856 unconjugated
Catalog No. ABIN2839580
  • Target See all CDC25A Antibodies
    CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
    Binding Specificity
    • 34
    • 33
    • 21
    • 17
    • 15
    • 12
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 480-514, pThr507
    Reactivity
    • 235
    • 93
    • 77
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    Human
    Host
    • 244
    • 7
    Rabbit
    Clonality
    • 245
    • 6
    Polyclonal
    Conjugate
    • 108
    • 21
    • 16
    • 15
    • 11
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 3
    • 3
    • 3
    • 3
    • 3
    This CDC25A antibody is un-conjugated
    Application
    • 193
    • 124
    • 69
    • 40
    • 40
    • 32
    • 21
    • 17
    • 15
    • 8
    • 7
    • 6
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Predicted Reactivity
    B, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CDC25A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T507 of human CDC25A.
    Clone
    RB7856
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CDC25A Primary Antibody
  • Application Notes
    IF: 1:25. WB: 1:250. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
    Expiry Date
    6 months
  • Chou, Yen, Lee, Chen: "Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain." in: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17833-45, (2010) (PubMed).

    Kasahara, Goto, Enomoto, Tomono, Kiyono, Inagaki: "14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage." in: The EMBO journal, Vol. 29, Issue 16, pp. 2802-12, (2010) (PubMed).

  • Target
    CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
    Alternative Name
    CDC25A (CDC25A Products)
    Synonyms
    cdc25a2 antibody, cdc25A antibody, sb:cb317 antibody, CDC25A2 antibody, D9Ertd393e antibody, cell division cycle 25A antibody, cell division cycle 25B antibody, cell division cycle 25A S homeolog antibody, CDC25A antibody, cdc25a antibody, cdc25b antibody, Cdc25a antibody, cdc25a.S antibody
    Background
    CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
    Molecular Weight
    59087
    NCBI Accession
    NP_001780, NP_963861
    UniProt
    P30304
    Pathways
    Cell Division Cycle, Mitotic G1-G1/S Phases, M Phase
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