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AD_K2 (AA 633-660), (C-Term) antibody

Reactivity: Human, Monkey, Mouse WB Host: Rabbit Polyclonal RB00896 unconjugated
Catalog No. ABIN2841169
  • Target
    AD_K2
    Binding Specificity
    AA 633-660, C-Term
    Reactivity
    Human, Monkey, Mouse
    Host
    • 1
    Rabbit
    Clonality
    • 1
    Polyclonal
    Conjugate
    • 1
    Un-conjugated
    Application
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This AD_K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human AD_K2.
    Clone
    RB00896
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Billard, Fitzhugh, Parker, Brozowski, McGinnis, Timoshchenko, Serafin, Lininger, Klauber-Demore, Sahagian, Truong, Sassano, Serody, Tarrant: "G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis." in: PLoS ONE, Vol. 11, Issue 4, pp. e0152856, (2016) (PubMed).

    Rao, Rapoport, Kim: "Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 6, pp. 851-60, (2009) (PubMed).

  • Target
    AD_K2
    Background
    The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85 % amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95 % similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
    Molecular Weight
    79710
    Gene ID
    157
    NCBI Accession
    NP_005151
    UniProt
    P35626
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