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HSP27 antibody (AA 108-136)

HSPB1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB19530 unconjugated
Catalog No. ABIN2841336
  • Target See all HSP27 (HSPB1) Antibodies
    HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))
    Binding Specificity
    • 42
    • 37
    • 27
    • 16
    • 16
    • 10
    • 8
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 108-136
    Reactivity
    • 300
    • 104
    • 90
    • 24
    • 14
    • 14
    • 13
    • 12
    • 11
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 238
    • 66
    Rabbit
    Clonality
    • 207
    • 96
    Polyclonal
    Conjugate
    • 138
    • 23
    • 17
    • 13
    • 12
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HSP27 antibody is un-conjugated
    Application
    • 257
    • 104
    • 104
    • 95
    • 70
    • 50
    • 49
    • 46
    • 41
    • 40
    • 16
    • 12
    • 10
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B, M, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This HSP27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-136 amino acids from the Central region of human HSP27.
    Clone
    RB19530
    Isotype
    Ig Fraction
    Top Product
    Discover our top product HSPB1 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))
    Alternative Name
    HSP27 (HSPB1 Products)
    Synonyms
    CMT2F antibody, HMN2B antibody, HS.76067 antibody, HSP27 antibody, HSP28 antibody, Hsp25 antibody, SRP27 antibody, 27kDa antibody, Hsp27 antibody, cb153 antibody, cb660 antibody, hsp1 antibody, hsp25 antibody, hsp27 antibody, id:ibd2821 antibody, sb:cb660 antibody, zgc:103437 antibody, HSPB1 antibody, cmt2f antibody, hs.76067 antibody, hsp28 antibody, heat shock protein family B (small) member 1 antibody, heat shock protein 1 antibody, heat shock protein, alpha-crystallin-related, 1 antibody, heat shock protein family B (small) member 1 L homeolog antibody, HSPB1 antibody, Hspb1 antibody, hspb1 antibody, hspb1.L antibody
    Background
    In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores, and high levels are associated with carcinoma of the breast and with endometrial adenocarcinomas. Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, causes a rapid phosphorylation of preexisting HSBP1, with Ser82 as the major site and Ser78 the minor site of phosphorylation. HSBP1 may exert phosphorylation-activated functions linked with growth signaling pathways in unstressed cells. A homeostatic function at this level could protect cells from adverse effects of signal transduction systems which may be activated inappropriately during stress.
    Molecular Weight
    22783
    Gene ID
    3315
    NCBI Accession
    NP_001531
    UniProt
    P04792
    Pathways
    MAPK Signaling, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, VEGF Signaling
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