beta 2 Adrenergic Receptor (BAR2) (AA 1-30), (N-Term) antibody

Catalog No. ABIN391396

Product Details

Target: beta 2 Adrenergic Receptor (BAR2)

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Specificity: This BAR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7~37 amino acids from the N-terminal region of human BAR2.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This beta 2 Adrenergic Receptor (BAR2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human beta 2 Adrenergic Receptor (BAR2).

Clone: RB10325

Isotype: Ig Fraction

Application Details

Application Notes: WB = 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.42 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References

Simkins, Crawford, Goudreau, Lookingland, Kaplan: "Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 9, Issue 4, pp. 544-57, (2014) (PubMed).

Rodrigues, Tran, Fortes, Schmid-Schönbein: "Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats." in: American journal of physiology. Heart and circulatory physiology, Vol. 299, Issue 1, pp. H25-35, (2010) (PubMed).

Target Details

Target: beta 2 Adrenergic Receptor (BAR2)

Background: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Synonyms: Beta-2 adrenoceptor, Beta-2 adrenoreceptor, ADRB2, ADRB2R, B2AR

Molecular Weight: 46426 DA

Gene ID: 154

NCBI Accession: NP_000015