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MCL-1 antibody (AA 191-226)

MCL1 Reactivity: Human, Mouse, Rat WB, FACS, IHC (p) Host: Rabbit Polyclonal RB00961 unconjugated
Catalog No. ABIN2846220
  • Target See all MCL-1 (MCL1) Antibodies
    MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
    Binding Specificity
    • 24
    • 22
    • 16
    • 11
    • 11
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 191-226
    Reactivity
    • 148
    • 83
    • 71
    • 6
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 145
    • 8
    • 2
    • 1
    Rabbit
    Clonality
    • 139
    • 19
    Polyclonal
    Conjugate
    • 73
    • 12
    • 12
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MCL-1 antibody is un-conjugated
    Application
    • 124
    • 66
    • 53
    • 45
    • 27
    • 26
    • 22
    • 22
    • 11
    • 9
    • 7
    • 5
    • 4
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-226 amino acids from human MCL1.
    Clone
    RB00961
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MCL1 Primary Antibody
  • Application Notes
    WB: 1:2000. WB: 1:2000. IHC-P: 1:10~50. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

    Tsang, Tang, Chan, Co, Au Yeung, Yau, Kong, Fung, Kwok: "P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells." in: Apoptosis : an international journal on programmed cell death, Vol. 16, Issue 5, pp. 524-35, (2011) (PubMed).

    Johnson, Lucas, Muthusamy, Smith, Edwards, De Lay, Croce, Grever, Byrd: "Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia." in: Blood, Vol. 108, Issue 4, pp. 1334-8, (2006) (PubMed).

    Yamane, Dylla, Muijtjens, Weissman: "Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 9, pp. 3312-7, (2005) (PubMed).

  • Target
    MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
    Alternative Name
    MCL1 (MCL1 Products)
    Synonyms
    BCL2L3 antibody, EAT antibody, MCL1-ES antibody, MCL1L antibody, MCL1S antibody, Mcl-1 antibody, TM antibody, bcl2-L-3 antibody, mcl1/EAT antibody, AW556805 antibody, mcl-1 antibody, fb72f02 antibody, wu:fb70a08 antibody, wu:fb72f02 antibody, zfMLP1 antibody, zfMcl-1a antibody, zgc:109835 antibody, zgc:109763 antibody, E3 antibody, E3-2 antibody, RNE3 antibody, RNU107 antibody, SNORA63A antibody, elF-4AII antibody, MCL1, BCL2 family apoptosis regulator antibody, myeloid cell leukemia sequence 1 antibody, MCL1, BCL2 family apoptosis regulator a antibody, MCL1, BCL2 family apoptosis regulator b antibody, small nucleolar RNA, H/ACA box 63 antibody, MCL1 antibody, Mcl1 antibody, mcl1a antibody, mcl1b antibody, SNORA63 antibody
    Background
    The Mcl-1 protein belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.
    Molecular Weight
    37337
    Gene ID
    4170
    NCBI Accession
    NP_001184249, NP_068779, NP_877495
    UniProt
    Q07820
    Pathways
    MAPK Signaling
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