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UVRAG antibody (C-Term)

UVRAG Reactivity: Human, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal RB10849 unconjugated
Catalog No. ABIN2849984
  • Target See all UVRAG Antibodies
    UVRAG (UV Radiation Resistance Associated Gene (UVRAG))
    Binding Specificity
    • 15
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 666-699, C-Term
    Reactivity
    • 64
    • 38
    • 30
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 60
    • 4
    Rabbit
    Clonality
    • 62
    • 2
    Polyclonal
    Conjugate
    • 27
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UVRAG antibody is un-conjugated
    Application
    • 57
    • 22
    • 13
    • 12
    • 12
    • 11
    • 9
    • 9
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-699 amino acids from the C-terminal region of human UVRAG.
    Clone
    RB10849
    Isotype
    Ig Fraction
    Top Product
    Discover our top product UVRAG Primary Antibody
  • Application Notes
    IF: 1:10~50. IF: 1:200. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Armstrong, Corazzari, Martin, Pagliarini, Falasca, Hill, Ellis, Al Sabah, Redfern, Fimia, Piacentini, Lovat: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, (2011) (PubMed).

    Sun, Zhang, Fan, Wong, Ding, Chen, Zhong: "The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression." in: The Journal of biological chemistry, Vol. 286, Issue 1, pp. 185-91, (2011) (PubMed).

    Neely, Green, LaFerla: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).

    Sun, Westphal, Wong, Tan, Zhong: "Rubicon controls endosome maturation as a Rab7 effector." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 45, pp. 19338-43, (2010) (PubMed).

    Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin: "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1371-83, (2010) (PubMed).

    Sun, Fan, Chen, Ding, Chen, Zhong: "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 49, pp. 19211-6, (2008) (PubMed).

    Han, Hou, Goldstein, Lu, Stolz, Yin, Rabinowich: "Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19665-77, (2008) (PubMed).

  • Target
    UVRAG (UV Radiation Resistance Associated Gene (UVRAG))
    Alternative Name
    UVRAG (UVRAG Products)
    Synonyms
    DHTX antibody, VPS38 antibody, p63 antibody, 9530039D02Rik antibody, AI648770 antibody, BB124205 antibody, Uvrag1 antibody, Uvragl antibody, zgc:56164 antibody, uvrag antibody, MGC81810 antibody, UVRAG antibody, MGC131135 antibody, CG6116 antibody, Dmel\\CG6116 antibody, UV radiation resistance associated antibody, UV radiation resistance associated gene antibody, UV radiation resistance associated S homeolog antibody, UV radiation resistance associated L homeolog antibody, UV-resistance associated gene antibody, UVRAG antibody, Uvrag antibody, uvrag antibody, uvrag.S antibody, uvrag.L antibody
    Background
    UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
    Molecular Weight
    78151
    Gene ID
    7405
    NCBI Accession
    NP_003360
    UniProt
    Q9P2Y5
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