RCAS1 antibody

Catalog No. ABIN1107048

Product Details anti-RCAS1 Antibody

Target: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RCAS1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Specificity: This antibody recognizes RCAS1.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein-L Sepharose

Immunogen: Human uterine cervical adenocarcinoma cell

Clone: 22-01-01

Isotype: IgM

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 100 μg IgG in 100 μLvolukme of PBS containing 50 % glycerol and 0.5 M NaCl, pH 7.2 No preservative is contained.

Preservative: Azide free

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for RCAS1

Target: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Alternative Name: EBAG9 / RCAS1 (EBAG9 Products)

Synonyms: EB9 antibody, PDAF antibody, MGC56608 antibody, zgc:56608 antibody, MGC84425 antibody, EBAG9 antibody, AI835379 antibody, Rcas1 antibody, RCAS1 antibody, eb9 antibody, pdaf antibody, rcas1 antibody, estrogen receptor binding site associated, antigen, 9 antibody, estrogen receptor binding site associated, antigen, 9 L homeolog antibody, estrogen receptor-binding fragment-associated gene 9 antibody, EBAG9 antibody, ebag9 antibody, ebag9.L antibody, Ebag9 antibody

Background: RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is a novel tumoreassociated antigen expressed in human uterine and ovarian carcinomas. The predicted amino acid sequence of RCAS1 (213 a.a.) possesses an N-terminal transmembrane region and a coiled-coil structure in the C-terminal portion, indicating that RCAS1 is a type II membrane protein able to form oligomers through the coiled-coil structure. RCAS1 revealed different expression pattern from the known tumore associated antigens such as, YH206, GA733, CA125, CEA and sialyl Le molecules in human tumore cell lines. Recent study indicated RCAS1 acts as a ligand for a putative receptor present on various human cells including T, B and NK cells. RCAS1 inhibited the in vitro growth of receptor-expressing cells and induced apoptosis. It was suggested that tumore cells might evade immune surveillance by expression of RCAS1.Synonyms: Cancer-associated surface antigen RCAS1, EB9, Estrogen receptor-binding fragment-associated gene 9 protein, PDAF, Receptor-binding cancer antigen expressed on SiSo cells

Gene ID: 9166

NCBI Accession: NP_004206

UniProt: O00559