CDCA8 antibody (N-Term)

Catalog No. ABIN1449290

Product Details anti-CDCA8 Antibody

Target: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Binding Specificity: AA 1-280, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDCA8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificity: This antibody reacts with Borealin (35 kDa).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogen: Recombinant full-length human Borealin (1-280 aa)

Clone: 1D11

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for CDCA8

Target: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Alternative Name: CDCA8 / Borealin (CDCA8 Products)

Synonyms: BOR antibody, BOREALIN antibody, DasraB antibody, MESRGP antibody, Bor antibody, Borr antibody, CG4454 antibody, Dmel\\CG4454 antibody, dBor antibody, borea antibody, Dasra-B antibody, GgDasraB antibody, 4831429J16Rik antibody, AU044747 antibody, Borealin antibody, D4Ertd421e antibody, bor antibody, dasrab antibody, borealin antibody, cdca8l antibody, sb:cb373 antibody, zgc:101607 antibody, cell division cycle associated 8 antibody, borealin-related antibody, Borealin antibody, cell division cycle associated 8 L homeolog antibody, CDCA8 antibody, borr antibody, borea antibody, Cdca8 antibody, cdca8.L antibody, cdca8 antibody

Background: Borealin is a subunit of the chromosomal passenger complex (CPC), which is necessary for chromosome segregation and cytokinesis. While CPC shows a dynamic localization pattern during mitosis, Borealin and survivin, another subunit of CPC is essential to localize CPC at centromare from prophase to anaphase. It is thought that Borealin and survivin recruit aurora B, a kinase subunit of CPC, to inner centromare to allow phosphorylating appropriate substrates.Synonyms: Cell division cycle-associated protein 8, Dasra-B, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein, hDasra-B

Gene ID: 55143

NCBI Accession: NP_060571

UniProt: Q53HL2

Pathways: Cell Division Cycle, M Phase