CDH6 antibody

Catalog No. ABIN2854396

Product Details anti-CDH6 Antibody

Target: CDH6 (K-Cadherin (CDH6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDH6 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to K-cadherin (cadherin 6, type 2, K-cadherin (fetal kidney))
K-cadherin antibody [N2C1], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human K-cadherin. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLa , Jurkat

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for CDH6

Target: CDH6 (K-Cadherin (CDH6))

Alternative Name: cadherin 6 (CDH6 Products)

Synonyms: KCAD antibody, K-cadherin antibody, cad6 antibody, cadherin-6 antibody, CAD6 antibody, c-cad6B antibody, cadherin 6 antibody, Cdh6 antibody, CDH6 antibody

Background: This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.

Cellular Localization: Cell membrane

Molecular Weight: 88 kDa

Gene ID: 1004

UniProt: P55285

Pathways: Cell-Cell Junction Organization