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MMP12 antibody

MMP12 Reactivity: Human WB, ICC, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2854843
  • Target See all MMP12 Antibodies
    MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
    Reactivity
    • 71
    • 35
    • 35
    • 4
    • 1
    Human
    Host
    • 89
    • 3
    • 2
    • 1
    Rabbit
    Clonality
    • 80
    • 15
    Polyclonal
    Conjugate
    • 40
    • 17
    • 13
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MMP12 antibody is un-conjugated
    Application
    • 84
    • 36
    • 34
    • 12
    • 11
    • 10
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Cross-Reactivity
    Human, Rat
    Characteristics
    Rabbit Polyclonal antibody to MMP12 (matrix metallopeptidase 12 (macrophage elastase))
    MMP12 antibody [N3C1], Internal
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MMP12. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product MMP12 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Validation: Orthogonal

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
    Alternative Name
    matrix metallopeptidase 12 (MMP12 Products)
    Synonyms
    MMP12 antibody, AV378681 antibody, Mmel antibody, Mme antibody, HME antibody, ME antibody, MME antibody, MMP-12 antibody, matrix metallopeptidase 12 antibody, MMP12 antibody, Mmp12 antibody
    Background
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

    Cellular Localization: Secreted , extracellular space , extracellular matrix
    Molecular Weight
    54 kDa
    Gene ID
    4321
    UniProt
    P39900
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