PTGS1 antibody (C-Term)

Catalog No. ABIN2855874

Product Details anti-PTGS1 Antibody

Target: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to COX1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase))
COX1 antibody [C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human COX1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Molt-4

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for PTGS1

Target: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Alternative Name: prostaglandin-endoperoxide synthase 1 (PTGS1 Products)

Synonyms: COX-1 antibody, cox-1 antibody, PTGS1 antibody, Ptgs1 antibody, COX1 antibody, Cox-1 antibody, Cox-3 antibody, PGHS-1 antibody, PHS 1 antibody, Pghs1 antibody, Cox1 antibody, Cox3 antibody, cox1 antibody, zCOX-1 antibody, COX3 antibody, PCOX1 antibody, PES-1 antibody, PGG/HS antibody, PGHS1 antibody, PHS1 antibody, PTGHS antibody, COX-3 antibody, prostaglandin-endoperoxide synthase 1 antibody, cyclooxygenase-1 antibody, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody, prostaglandin-endoperoxide synthase 1 S homeolog antibody, PTGS1 antibody, cox-1 antibody, Ptgs1 antibody, ptgs1 antibody, ptgs1.S antibody

Background: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

Cellular Localization: Microsome membrane, Peripheral membrane protein , Endoplasmic reticulum membrane, Peripheral membrane protein

Molecular Weight: 69 kDa

Gene ID: 5742

UniProt: P23219