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SOCS5 antibody (N-Term)

SOCS5 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2855921
  • Target See all SOCS5 Antibodies
    SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))
    Binding Specificity
    • 15
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 29
    • 3
    • 2
    Human, Mouse
    Host
    • 25
    • 3
    • 1
    Rabbit
    Clonality
    • 28
    • 1
    Polyclonal
    Conjugate
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SOCS5 antibody is un-conjugated
    Application
    • 26
    • 13
    • 13
    • 9
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Rat (Rattus), Pig (Porcine), Chicken, Rhesus Monkey, Cow (Bovine)
    Cross-Reactivity (Details)
    Rat (100 %), Pig (100 %), Chicken (100 %), Rhesus Monkey (100 %), Bovine (100 %)
    Characteristics
    Rabbit Polyclonal antibody to SOCS5 (suppressor of cytokine signaling 5)
    SOCS5 antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SOCS5. The exact sequence is proprietary.
    Isotype
    IgG
  • Application Notes
    Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
    Comment

    Positive Control: Molt-4 , NT2D1 , PC-3 , mouse testis

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    1XPBS, 40 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Cui, Chen, Zhang, Cheng, Pan, Huang, Hu, Zhang, Wang, Zhu, Chen, Liu, Zhao, Wu, Yang, Liu, Zhang, Yu, Yin, Jing, Rehman, Tian, Pan, Jia: "Duck Tembusu Virus Utilizes miR-221-3p Expression to Facilitate Viral Replication via Targeting of Suppressor of Cytokine Signaling 5." in: Frontiers in microbiology, Vol. 11, pp. 596, (2020) (PubMed).

    Tsai, Kuo, Hung, Wu, Wu, Chang, Kuo, Hsu: "Angpt2 Induces Mesangial Cell Apoptosis through the MicroRNA-33-5p-SOCS5 Loop in Diabetic Nephropathy." in: Molecular therapy. Nucleic acids, Vol. 13, pp. 543-555, (2018) (PubMed).

  • Target
    SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))
    Alternative Name
    SOCS5 (SOCS5 Products)
    Synonyms
    SOCS5 antibody, cis6 antibody, cish5 antibody, cish6 antibody, socs-5 antibody, GB18949 antibody, socs5 antibody, zgc:153506 antibody, CIS6 antibody, CISH6 antibody, Cish5 antibody, SOCS-5 antibody, 1810018L08Rik antibody, mKIAA0671 antibody, RGD1564914 antibody, suppressor of cytokine signaling 5 antibody, suppressor of cytokine signaling 5a antibody, suppressor of cytokine signaling 5 L homeolog antibody, SOCS5 antibody, socs5 antibody, LOC552036 antibody, socs5a antibody, Tsp_07018 antibody, socs5.L antibody, Socs5 antibody
    Background
    The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.

    Molecular Weight
    61 kDa
    Gene ID
    9655
    Pathways
    JAK-STAT Signaling, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process
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