CYP46A1 antibody (Center)

Catalog No. ABIN2856057

Product Details anti-CYP46A1 Antibody

Target: CYP46A1 (Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1))

Binding Specificity: Center

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP46A1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Cross-Reactivity (Details): Human (100 %)

Characteristics: Rabbit Polyclonal antibody to CYP46A1 (cytochrome P450, family 46, subfamily A, polypeptide 1)
CYP46A1 antibody [N1C2]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CYP46A1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Comment:

Positive Control: Mouse brain

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for CYP46A1

Target: CYP46A1 (Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1))

Alternative Name: CYP46A1 (CYP46A1 Products)

Synonyms: CP46 antibody, CYP46 antibody, CYP46A1 antibody, zgc:109896 antibody, MGC147389 antibody, Cyp46 antibody, cytochrome P450 family 46 subfamily A member 1 antibody, cytochrome P450 family 46 subfamily A member 1 L homeolog antibody, cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1 antibody, cytochrome P450, family 46 antibody, cytochrome P450 46A1 antibody, cytochrome P450, family 46, subfamily a, polypeptide 1 antibody, cholesterol 24-hydroxylase antibody, cytochrome P450, family 46, subfamily A, polypeptide 1 antibody, CYP46A1 antibody, cyp46a1.L antibody, cyp46a1.1 antibody, cyp46a1 antibody, PTRG_08343 antibody, PTRG_09667 antibody, Cyp46a1 antibody, Sgly_1093 antibody

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Cellular Localization: Endoplasmic reticulum membrane , Microsome membrane

Molecular Weight: 57 kDa

Gene ID: 10858