MMP17 antibody

Catalog No. ABIN2856073

Product Details anti-MMP17 Antibody

Target: MMP17 (Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP17 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)

Cross-Reactivity: Human

Characteristics: Rabbit Polyclonal antibody to MMP17 (matrix metallopeptidase 17 (membrane-inserted))
MMP17 antibody [N2C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human MMP17. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLa

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.74 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for MMP17

Target: MMP17 (Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17))

Alternative Name: matrix metallopeptidase 17 (MMP17 Products)

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.

Cellular Localization: Isoform Long: Cell membrane, Lipid-anchor , GPI-anchor, Extracellular side , Secreted , extracellular space , extracellular matrix

Molecular Weight: 67 kDa

Gene ID: 4326

UniProt: Q9ULZ9