GSTZ1 antibody

Catalog No. ABIN2856258

Product Details anti-GSTZ1 Antibody

Target: GSTZ1 (Glutathione Transferase zeta 1 (Maleylacetoacetate Isomerase) (GSTZ1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTZ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Cross-Reactivity: Human

Characteristics: Rabbit Polyclonal antibody to GSTZ1 (glutathione transferase zeta 1)
GSTZ1 antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Grade: KO Validated

Immunogen: Recombinant protein encompassing a sequence within the center region of human GSTZ1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: 293T

Validation: KO/KD, Orthogonal, Overexpression

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.98 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-GSTZ1 antibody (ABIN2856258)

Lei, Wang, Tang, Wang: "GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells." in: FEBS open bio, Vol. 10, Issue 1, pp. 6-17, (2020) (PubMed).

Li, Wang, Yang, Lei, Yang, Liang, Chen, Xia, Wang, Tang: "GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway." in: Journal of experimental & clinical cancer research : CR, Vol. 38, Issue 1, pp. 438, (2020) (PubMed).

Target Details for GSTZ1

Target: GSTZ1 (Glutathione Transferase zeta 1 (Maleylacetoacetate Isomerase) (GSTZ1))

Alternative Name: glutathione S-transferase zeta 1 (GSTZ1 Products)

Synonyms: GSTZ1-1 antibody, MAAI antibody, MAI antibody, zgc:113898 antibody, zgc:92869 antibody, PSPTO3554 antibody, DDBDRAFT_0204466 antibody, DDBDRAFT_0231608 antibody, DDB_0204466 antibody, DDB_0231608 antibody, CG9362 antibody, Dmel\CG9362 antibody, gstz1 antibody, glutathione S-transferase zeta 1 antibody, glutathione transferase zeta 1 (maleylacetoacetate isomerase) antibody, maleylacetoacetate isomerase antibody, Glutathione S transferase Z1 antibody, glutathione S-transferase zeta 1 L homeolog antibody, GSTZ1 antibody, Gstz1 antibody, gstz1 antibody, maiA antibody, hmgC antibody, Patl_1448 antibody, Pnap_2807 antibody, Bind_0562 antibody, Bphyt_0577 antibody, Dtpsy_1678 antibody, Hbal_2638 antibody, mai antibody, BC1002_0299 antibody, Fbal_2576 antibody, Mesop_3937 antibody, GstZ1 antibody, gstz1.L antibody

Background: This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.

Cellular Localization: Cytoplasm

Molecular Weight: 24 kDa

Gene ID: 2954

UniProt: O43708