RIC8A antibody (C-Term)
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- Target See all RIC8A Antibodies
- RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RIC8A antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Rat (Rattus), Cow (Bovine)
- Cross-Reactivity (Details)
- Rat (100 %), Bovine (100 %)
- Characteristics
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Rabbit Polyclonal antibody to RIC8A (resistance to inhibitors of cholinesterase 8 homolog A (C. elegans))
RIC8A antibody - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RIC8A. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product RIC8A Primary Antibody
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- Application Notes
- Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
- Comment
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Positive Control: A431 , H1299 , HeLa , HepG2 , Raji
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.85 mg/mL
- Buffer
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))
- Alternative Name
- RIC8A (RIC8A Products)
- Synonyms
- RIC8 antibody, AI114950 antibody, RIC-8 antibody, Ric8a antibody, Ric-8A antibody, Ric8 antibody, ric-8 antibody, ric8 antibody, synembryn antibody, xtric-8 antibody, zgc:92294 antibody, Syn antibody, ric8a antibody, ric8ab antibody, CG15797 antibody, DmRic8 antibody, Dmel\\CG15797 antibody, Ric-8 antibody, l(1)G0397 antibody, ric-8a antibody, ricc8aa antibody, fj97c10 antibody, synbl antibody, wu:fj97c10 antibody, RIC8 guanine nucleotide exchange factor A antibody, microRNA 6743 antibody, synembryn-A antibody, RIC8 guanine nucleotide exchange factor A L homeolog antibody, CG15797 gene product from transcript CG15797-RB antibody, synembryn antibody, RIC8 guanine nucleotide exchange factor A S homeolog antibody, Synembryn antibody, RIC8 guanine nucleotide exchange factor B antibody, RIC8A antibody, Ric8a antibody, ric8a antibody, MIR6743 antibody, Tsp_08768 antibody, ric8a.L antibody, LOC411841 antibody, ric8a.S antibody, ric-8 antibody, ric8b antibody
- Background
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Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
- Molecular Weight
- 60 kDa
- Gene ID
- 60626
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Asymmetric Protein Localization
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