GCM2 antibody (Center)

Catalog No. ABIN2856796

Product Details anti-GCM2 Antibody

Target: GCM2 (Glial Cells Missing Homolog 2 (GCM2))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCM2 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Rabbit polyclonal antibody to GCM2 (glial cells missing homolog 2 (Drosophila))
GCM2 antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human GCM2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Comment:

Positive Control: A431

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.75 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for GCM2

Target: GCM2 (Glial Cells Missing Homolog 2 (GCM2))

Alternative Name: GCM2 (GCM2 Products)

Synonyms: GCMb antibody, Gcm-2 antibody, gcm-2 antibody, GCMB antibody, hGCMb antibody, Gcm-rs1 antibody, Gcm1 antibody, Gcm1-rs2 antibody, glial cells missing homolog 2 antibody, glial cells missing homolog 2 (Drosophila) antibody, glial cells missing homolog 2 S homeolog antibody, GCM2 antibody, gcm2 antibody, gcm2.S antibody, Gcm2 antibody

Background: This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.

Cellular Localization: Nucleus

Molecular Weight: 57 kDa

Gene ID: 9247