GRPR antibody

Catalog No. ABIN2857015

Product Details anti-GRPR Antibody

Target: GRPR (Gastrin-Releasing Peptide Receptor (GRPR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRPR antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Rabbit polyclonal antibody to GRPR (gastrin-releasing peptide receptor)
GRPR antibody [C1C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human GRPR. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLaS3 , Molt-4 , mouse pancreas , mouse brain , rat brain , rat pancreas

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for GRPR

Target: GRPR (Gastrin-Releasing Peptide Receptor (GRPR))

Alternative Name: gastrin releasing peptide receptor (GRPR Products)

Synonyms: GRPR antibody, GRP-R antibody, gastrin releasing peptide receptor antibody, GRPR antibody, Grpr antibody

Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

Cellular Localization: Cell membrane, Multi-pass membrane protein

Molecular Weight: 43 kDa

Gene ID: 2925

UniProt: P30550