Fibrinogen antibody (FITC)

Details for Product anti-Fibrinogen Antibody No. ABIN2859190, Supplier: Log in to see
Antigen
  • fib2
  • MGC53620
  • fibrinogen
  • sb:cb892
  • wu:fa55c12
  • wu:fb20e08
  • wu:fb59b03
  • wu:fi39d04
  • zgc:92117
  • fibrinogen alpha chain
  • fibrinogen gamma chain
  • fga
  • FGA
  • CpipJ_CPIJ010090
  • FGG
Reactivity
Human, Pig (Porcine), Rat (Rattus), Rabbit
314
86
55
32
28
24
13
4
1
1
1
Host
Chicken
158
158
129
62
8
3
Clonality
Polyclonal
Conjugate
This Fibrinogen antibody is conjugated to FITC
46
46
44
7
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6
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Application
Flow Cytometry (FACS)
332
257
54
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42
40
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35
33
28
26
20
19
15
9
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6
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Options
Supplier
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Immunogen Purified, full length native fibrinogen Q9UE34
Isotype IgY
Cross-Reactivity (Details) Not reactive in: no confirmed exceptions from predicted reactivity known in the moment
Predicted Reactivity bovine, mouse
Characteristics Expected / apparent Molecular Weight of the Antigene: 24 kDa
Purification affinity purified
Background Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000, Rapold et al. 1989).
Molecular Weight 24 kDa
UniProt Q9UE34
Research Area Cardiovascular, Atherosclerosis, Extracellular Matrix, Coagulation
Application Notes 1: 10 (FC)
Comment

the antibodies have been shown to react with activated human, porcine, rat and rabbit platelets

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 0.15 M sodium chloride 0.02 M sodium phosphate 0.1 % sodium azide pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Make aliquots to avoid repreated freeze-thaw cycles and working with a stock.
Storage 4 °C
Storage Comment store at 4°C, make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Background publications Terada, Mori, Okazaki, Satake, Tadokoro: "Effects of riboflavin and ultraviolet light treatment on platelet thrombus formation on collagen via integrin ?IIb?3 activation." in: Transfusion, Vol. 54, Issue 7, pp. 1808-16, 2014 (PubMed).

Schmidt, Zündorf, Grüger, Brandenburg, Reiners, Zinserling, Witte, Schnitzler: "Phenotyping of Staphylococcus aureus reveals a new virulent ST398 lineage." in: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Vol. 19, Issue 3, pp. 279-85, 2013 (PubMed).

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