PAK2 antibody (P21-Activated Kinase 2)

Details for Product anti-PAK2 Antibody No. ABIN2869426, Supplier: Log in to see
Antigen
  • pak2
  • cb422
  • kinase
  • zgc:91798
  • wu:fb71h01
  • si:dz198m22.1
  • pak65
  • pakgamma
  • PAK65
  • PAKgamma
  • 5330420P17Rik
  • A130002K10Rik
  • AI836325
  • D16Ertd269e
  • PAK-2
  • mKIAA4182
  • gamma-PAK
  • PAKI
  • Pak3
  • p21 (CDKN1A)-activated kinase 2a
  • p21 protein (Cdc42/Rac)-activated kinase 2
  • pak2a
  • pak2
  • PAK2
  • Pak2
Alternatives
anti-Human PAK2 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Monkey
185
97
92
11
8
1
Host
Mouse
167
18
Clonality (Clone)
Monoclonal ()
Conjugate
This PAK2 antibody is un-conjugated
4
4
4
4
4
4
Application
ELISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)
166
100
75
36
19
6
5
4
3
2
2
1
Options
Supplier
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Purpose Purified Mouse Monoclonal Antibody
Immunogen Purified recombinant fragment of PAK2 expressed in E. Coli.

Antigen Type: Recombinant Protein
Clone 3B5
Isotype IgG1
Characteristics Synonyms: Serine/threonine-protein kinase PAK 2, 2.7.11.1, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, PAK-2, p58, PAK-2p27, p27, PAK-2p34, p34, C-t-PAK2, PAK2
Alternative Name PAK2 (PAK2 Antibody Abstract)
Background PAK2, also known as P21 (CDKN1A)-activated kinase 2. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. PAK2 has been shown to interact with SH3KBP1, CDC42 and Abl gene.
Molecular Weight 58043 Da
Gene ID 5062
NCBI Accession NP_002568
UniProt Q13177
Research Area Kinases/Phosphatases, Apoptosis/Necrosis, Cancer, Tyrosine Kinases
Pathways MAPK Signaling, RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
Application Notes The suggested dilution is: Western Bloting: = 1:500 - 2000. Immunohistochemistry: = 1:200 - 1000. Immunofluorescence: = 1:200 - 1000.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Machuy, Campa, Thieck, Rudel: "c-Abl-binding protein interacts with p21-activated kinase 2 (PAK-2) to regulate PDGF-induced membrane ruffles." in: Journal of molecular biology, Vol. 370, Issue 4, pp. 620-32, 2007 (PubMed).

Chu, Wu, Liao, Pardo, Zhao, Li, Mendenhall, Pali, Shen, Yu, Taylor, Aversa, Molineaux, Payan, Masuda: "A novel role for p21-activated protein kinase 2 in T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7324-34, 2004 (PubMed).

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