JAK3 antibody (Tyrosine-Protein Kinase JAK3)

Details for Product anti-JAK3 Antibody No. ABIN2869455, Supplier: Log in to see
Antigen
  • JAK-3
  • JAK3_HUMAN
  • JAKL
  • L-JAK
  • LJAK
  • fae
  • wil
  • RATJAK3
  • JAK
  • Janus kinase 3
  • JAK3
  • Jak3
Alternatives
anti-Mouse (Murine) JAK3 antibody for ELISA
Reactivity
Human, Mouse (Murine)
99
64
46
2
2
2
2
2
1
Host
Mouse
71
31
1
Clonality (Clone)
Monoclonal ()
Conjugate
This JAK3 antibody is un-conjugated
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Western Blotting (WB)
56
40
27
17
17
12
9
6
6
4
1
1
1
Options
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Purpose Purified Mouse Monoclonal Antibody
Immunogen Purified recombinant fragment of human JAK3 expressed in E. Coli.

Antigen Type: Recombinant Protein
Clone 5H2
Isotype IgG1
Characteristics Synonyms: Tyrosine-protein kinase JAK3, 2.7.10.2, Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK, JAK3
Alternative Name JAK3 (JAK3 Antibody Abstract)
Background JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Molecular Weight 125099 Da
Gene ID 3718
NCBI Accession NP_000206
UniProt P52333
Research Area Signaling, Receptors, Kinases/Phosphatases, Cytokines
Pathways JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation
Application Notes Western Bloting: = 1:500 - 2000, Immunofluorescence: = 1:200 - 1000.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Wood, Goodman, Uckun: "Jak3 expression and genomic sequence in pediatric acute lymphoblastic leukemia." in: Leukemia & lymphoma, Vol. 43, Issue 12, pp. 2355-62, 2003 (PubMed).

Lai, Jin, Graham, Witthuhn, Ihle, Liu: "A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells." in: The Journal of biological chemistry, Vol. 270, Issue 42, pp. 25028-36, 1995 (PubMed).

Kawamura, McVicar, Johnston, Blake, Chen, Lal, Lloyd, Kelvin, Staples, Ortaldo: "Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 14, pp. 6374-8, 1994 (PubMed).