4F2 Heavy Chain (4F2hc:CD98) antibody

Antigen: 4F2 Heavy Chain (4F2hc:CD98)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Rat (Rattus)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN289964

Additional Information

Immunogen: Partial peptide of Rat 4F2 Heavy Chain (4F2hc:CD98)

Format: Affinity-purified

Description: Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection ofamoino acid molecule variety, and is classfied into various transport systems by the transportative substrateselectivity and the Na+ dependence with the reflection of amino acid molecule variety.4F2 heavy chain (4F2hc:CD98) is originally identified as a cell-surface antigen which is upregulated bylymphocyte activation, and is a single memblane-spanning protein, of which molecular weight is under85-kDa .The transporter corresponds to the amino acid transporter, system L, y+L, Xc,and asc, whichrequires 4F2hc for its functional expression. 4F2hc and its associated transporters are linked via disulfideband to form heterodimeric complexes. 4F2hc is present at cell membrane in blood vessel side ofepitherliocyte, and transports its associated transporters to cell membrane of blood vessel in epitherliocyte.This antidody has been proved to be useful for immunohistochemistry and immunoblotting.Considering the peptide amino acid sequence, this antibody also seems to react with mouse 4F2hc.

Application Details

Application Notes: Working dilution ,for imunohistochemitry: 5-10ug/ml, for immunoblotting: 0.1-1ug/ml

Concentration: 0.1 mg/ml

Purification: This antibody was purified from rabbit serum immunized with synthesized peptideof C- end of rat 4F2hc by peptide affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Storage: Store below -20

Restrictions: For Research Use only

Images

Rat Kidney (frozen section)

4F2hc LAT Transporter Family Heterodimeric Complex