Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 4 (LGR4) antibody

Antigen: Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 4 (LGR4)

Synonyms: GPR48

Clonality: Monoclonal (12H6)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS), Western Blotting (WB)

Catalog no.: ABIN290064

Additional Information

Alternative name: LGR4

Immunogen: plasmid vector

Format: Affinity-purified

Isotype: IgG2a kappa  (Matching secondary antibodies)

Clone: 12H6

Description: LGR4, also known as GPR48, is a member of the leucine-rich repeat (LRR)-containing G protein-coupled receptor (LGR) family. LGR4 is composed of theextracellular domain containing 18 LRRs, the seven-transmembrane region. LGR4 is widely expressed in ovary, testis, adrenal, placenta, thymus, spinal cord, andthyroid in human.The LGR4 knockout mice show intrauterine growth retardation, remarkable decreases in the kidney and liver weights, suggesting that LGR4 plays important role forembryonic growth, especially for kidney and liver development. A study, by use of the LGR4 hypomorphic mutant mice, showed that the homozygous male isinfertile, showing morphologic abnormality in both the testes and the epididymides. Moreover, it has been demonstrated that up-regulation of LGR4 enhancescarcinoma cell invasiveness and metastasis.This antibody is specific to LGR4 and will be useful for research on embryonic growth, postnatal development, tumor invasiveness and metastasis.

Application Details

Application Notes: WB 0.5-1.0 ug/ml. IHC Not tested. ICC Not tested. ELISA Not tested. FCM 1.0-5.0 ug/ml. Neutralization Not tested. IP Not tested

Concentration: 0.25 mg/ml

Purification: Protein G

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Storage: Store below -20

Restrictions: For Research Use only