omega-3 Fatty Acid Receptor 1 (O3FAR1) antibody

Antigen: omega-3 Fatty Acid Receptor 1 (O3FAR1)

Clonality: Monoclonal (2B6)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS)

Catalog no.: ABIN290065

Additional Information

Alternative name: GPR120

Immunogen: Partial peptide of Human GPR120

Format: Affinity-purified

Isotype: IgG2a kappa  (Matching secondary antibodies)

Clone: 2B6

Description: GPR120 is a member of G protein-coupled receptor (GPCR) family and functions as a specific receptor for unsaturated long-chain free fatty acids (FFAs) such aspalmitoleic acid, alpha-linolenic acid, docosahexaenoic acid. The expression of GPR120 is widely detected in various tissues, and GPR120 is highly expressed in th epituitary, lung, small intestine, colon, and adipose tissues.It has been shown that the stimulation of GPR120 by FFAs promotes the secretion of GLP-1, known as the most potent insulinotropic incretin, from the gastrointestinal tract. It has been also demonstrated that FFAs stimulate the ERK and PI3K-Akt pathways through GPR120 and lead to anti-apoptotic effect in enteroendocrine cell line, and that GPR120 regulates adipogenic process such as adipocyte development and differentiation. In addition, a study suggested that GPR120 is expressed in the taste bud cells in circumvallate papillae to sense dietary fat.This antibody is specific to GPR120 and will be useful for research on diabetes, obesity.

Application Details

Application Notes: WB Not tested. IHC Not tested. ICC Not tested. ELISA Not tested. FCM 1.0-5.0 ug/ml. Neutralization Not tested. IP Not tested

Concentration: 0.25 mg/ml

Purification: Protein G

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Storage: Store below -20

Restrictions: For Research Use only