B and T Lymphocyte Associated (BTLA) antibody

Antigen: B and T Lymphocyte Associated (BTLA)

Synonyms: BTLA1, CD272, FLJ16065, MGC129743, MGC124217, MGC124218, A630002H24, BTLA

Clonality: Monoclonal (MIH26)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Catalog no.: ABIN298952

Additional Information

Alternative name: BTLA

Swiss-Prot: Q7Z6A9

Immunogen: BTLA - transfected L cells.

Isotype: IgG2b  (Matching secondary antibodies)

Clone: MIH26

Description: Gene: BTLA, Standard Gene Symbol: BTLA, Synonyms: BTLA, BTLA1, CD272, FLJ16065, MGC129743

Specificity: Detects human CD272, also known as B- and T-lymphocyte attenuator (BTLA). CD272 is a type I transmembrane glycoprotein which is structurally and functionally related to cytotoxic T lymphocyte antigen-4 (CTLA-4), and programmed death-1 (PD-1). CD272 is a T-cell inhibitory receptor that regulates T cell activation through its interaction with herpes virus entry mediator (HVEM), a co-stimulator receptor of the TNFR family. CD272 may negatively regulate T-cell dependent autoimmune reaction, and polymorphisms in its gene have been associated with Rheumatoid Arthritis

Application Details

Application Notes: Flo (1:10 - 1:200), IHC-Fr

Concentration: 1 mg/ml

Purification: Affinity Chromatography

Buffer: PBS, pH 7.4, 0.09% sodium azide.

Storage: +4°C or -20°C, Avoid repeated freezing and thawing.

Restrictions: For Research Use only