Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) antibody

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D)

Synonyms: DCR2, CD264, TRUNDD, TRAILR4, TNFRSF10D

Clonality: Monoclonal (TRAIL-R4-01)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS)

Catalog no.: ABIN301992

Additional Information

Alternative name: CD264 / TRAIL-R4

Immunogen: TRAIL-R4 (aa 1-210) - hIgGhc fusion protein

Format: Azide Free

Isotype: IgG1  (Matching secondary antibodies)

Clone: TRAIL-R4-01

Description: TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells,belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis inmany tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncateddeath domain, thus it is unable to induce apoptosis and serves as a negative regulator ofapoptotic signaling by impairment death-inducing signaling complex (DISC) processing.TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependentmanner and prevents its corecruitment with death receptor 4 (DR4).

Specificity: The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane proteinexpressed on various blood cells.

Application Details

Concentration: 1 mg/ml

Purity: > 95% (by SDS-PAGE)

Purification: Purified from ascites by protein-A affinity chromatography.

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 µ m filter sterilized.

Storage: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Restrictions: For Research Use only