Syndecan 1 (SDC1) antibody

Antigen: Syndecan 1 (SDC1)

Synonyms: SDC, CD138, SYND1, syndecan, Sstn, Synd, Synd1, syn-1, AA408134, AA409076, sdc, Syn1, cd138, synd1, xSyn1, syndecan1, Syndecan-1, XSyndecan-1, HSPG, SYNDECA, Syndecan, SDC1, MGC139976

Clonality: Monoclonal (B-A38)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS)

Catalog no.: ABIN301993

Additional Information

Alternative name: CD138

Immunogen: U266 human peripheral blood myeloma cell line

Format: Azide Free

Isotype: IgG1  (Matching secondary antibodies)

Clone: B-A38

Description: CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokinesand modulate their activity, as well as the activity of extracellular matrix components andinfluence many developmental processes. CD138 is expressed mainly in differentiatingkeratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury.It is also highly expressed on plasma cells and can be detected even on fibroblasts,vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation ofCD138 on the cell surface often correlates with the gain of cancerous characteristics. Serumlevels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.

Specificity: The antibody B-A38 recognizes CD138 (syndecan 1), a 65-70 kDa heparan sulfateproteoglycan expressed mainly in the epidermis and plasma cells, but also in growthfactor-stimulated lymphocytes.

Application Details

Concentration: 1 mg/ml

Purity: > 95% (by SDS-PAGE)

Purification: Purified by ion exchange chromatography.

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 µ m filter sterilized.

Storage: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Research Area: CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only