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CD8a Molecule (CD8A) antibody (Biotin)
| Antigen | CD8a Molecule (CD8A) |
| Synonyms | CD8, MAL, p32, Leu2, Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, MGC136643, zgc:136643, cd8, LOC100136450 |
| Clonality | Monoclonal (MEM-87) |
| Host |
 Alternatives Mouse |
| Reactivity |
Alternatives Human |
| Conjugate |
Alternatives Biotin |
| Catalog no. | ABIN301999 |
| Quantity | 0.1 mg (1 mg/ml) |
| Price | 325.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 3 to 5 Business Days |
Additional Information
| Alternative name | CD8 |
| Immunogen | Leukocytes of a patient suffering from LGL Type Leukemia. |
| Isotype | IgG1 |
| Clone | MEM-87 |
| Description | The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/betaheterodimer on majority of MHC I-restricted conventional T cells and thymocytes and asalpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cellsand dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an importantmechanism to control their effector function. Assembly of CD8 alpha-beta but notalpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruitingtriggered TCR complexes to these membrane microdomains as well as affinity of TCR toMHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. |
| Specificity | The antibody MEM-87 recognizes CD8, a cell surface glycoprotein found on most cytotoxicT lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 isa disulfide-linked dimer and exists as a CD8 alpha/alpha homodimer or CD8 alpha/betaheterodimer (each monomer approx. 32-34 kDa). |
Application Details
| Application Notes | Biotinylated antibody is designed for indirect immunofluorescence analysis by FlowCytometry. Suggested working dilution is 5-10 µg/ml. Indicated dilution is recommended starting pointfor use of this product. Working concentrations should be determined by the investigator. |
| Concentration | 1 mg/ml |
| Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage | Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles. |
| Research Area | Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "CD8a Molecule (CD8A)", type "Antibodies"
