Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody (FITC)

Antigen: Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2)

Synonyms: C3DR, CD21, SLEB9

Clonality: Monoclonal (LT21)

Host: Mouse

Reactivity: Human, Pig (Porcine), Cow (Bovine), Dog (Canine)

Conjugate: FITC

Application: Flow Cytometry (FACS)

Catalog no.: ABIN302019

Additional Information

Alternative name: CD21

Immunogen: IM9 human B-lymphoblastoid cell line

Isotype: IgG1

Clone: LT21

Description: CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially itsbreakdown fragments, which remain covalently attached to complement activating surfacesor antigen. CD21 has important roles in uptake and retention of immunocomplexes, survivalof memory B cells and in development and maintenance of the humoral response toT-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus bindingand is involved in targeting prions to folicular dendritic cells and expediting neuroinvasionfollowing peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed fromthe lymphocyte surface and retains its ability to bind respective ligands.

Specificity: The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein(complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells,some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature Bcells.HLDA VI, WS Code B CD21.1

Application Details

Application Notes: The reagent is designed for Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 10 6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

Storage: Store in the dark at 2-8 o C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.Short-term exposure to room temperature should not affect the quality of the reagent.However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Research Area: CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only