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GABA B Receptor GB2 Subunit antibody
| Antigen | GABA B Receptor GB2 Subunit |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Mouse (Murine), Rat (Rattus) |
| Application |
Western Blotting (WB), Immunocytochemistry (ICC)
|
| Catalog no. | ABIN302104 |
| Quantity | 0.1 mg (1 mg/ml) |
| Price | 325.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 3 to 5 Business Days |
Additional Information
| Immunogen | Synthetic peptide (coupled with THG) derived from the last 23 aa of mouse GABA Breceptor 2. 100% homology with human GB2. |
| Format | Purified |
| Description | GABA B receptor is a G-protein-coupled inhibitory receptor of gamma-aminobutyric acid(GABA), and has important functions in brain by inhibition of adenylyl cyclase andmodulation of G-protein-gated Ca 2+ and K + channels. GABA B receptor is comprised of two subunits, GB1 and GB2 with N-terminal extracellular and C-terminal intracellular domains.The GB1 subunit plays a critical role in ligand binding, whereas the GB2 subunit containsthe determinants required for G-protein signaling. Multiple allosteric interactions between thetwo subunits are required for correct functioning of the receptor. There are two N-terminalsplice variants of GB1 subunit, termed GB1a and GB1b, their expression in the centralnervous system changes during the ontogenesis and differs between various regions of thebrain. |
| Specificity | The polyclonal antibody recognizes C-terminus of gamma-aminobutyric acid (GABA) Breceptor 2 (recognized epitope: the last 23 aa). GB2 apparent MW ~120 kDa. |
Application Details
| Application Notes | Western Blotting - Recommended dilution: 0.6 µg/ml |
| Concentration | 1 mg/ml |
| Purity | > 95% (by SDS-PAGE) |
| Purification | Purified from rabbit serum by protein-G affinity chromatography. |
| Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage | Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles. |
| Restrictions | For Research Use only |
