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Endoglin (ENG) antibody (PE)

Details for Product No. ABIN302200, Supplier: Login to see
Antigen
  • ENG
  • MGC137842
  • DKFZp469D0419
  • END
  • HHT1
  • ORW1
  • AI528660
  • AI662476
  • CD105
  • S-endoglin
Reactivity
Human, Pig (Porcine)
385
137
47
12
11
7
5
5
5
3
1
1
1
Host
Mouse
232
187
66
4
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
PE
51
50
36
19
7
6
5
4
4
4
4
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Flow Cytometry (FACS)
276
275
120
102
86
49
42
41
26
14
12
11
9
7
6
3
3
3
3
2
2
2
2
2
1
1
1
1
Supplier
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Immunogen Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA
Clone MEM-229
Isotype IgG2a
Specificity This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Cross-Reactivity (Details) Species reactivity (tested):Human and Porcine.
Characteristics Synonyms: ENG, END, HHT1, ORW, ORW1
Purification Size-Exclusion Chromatography
Alternative Name CD105 / Endoglin (ENG Antibody Abstract)
Background CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.Synonyms: END, ENG, HHT1, ORW, ORW1
UniProt P17813
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways
Application Notes Flow Cytometry analysis of Human blood cells using 20 μL reagent/100 μL of whole blood or10^6 cells in a suspension.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline (PBS) containing 15 mM Sodium Azide and 0.2 % (w/v) high-grade protease free BSA as a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Immunofluorescence (IF) image for anti-Endoglin (ENG) antibody (PE) (ABIN302200) anti-Endoglin (ENG) antibody (PE)
Background publications Piao, Tokunaga: "Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study." in: Journal of atherosclerosis and thrombosis, Vol. 13, Issue 2, pp. 82-9, 2006 (PubMed).

Warrington, Hillarby, Li et al.: "Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells." in: Anticancer research, Vol. 25, Issue 3B, pp. 1851-64, 2005 (PubMed).

Guo, Slevin, Li et al.: "CD105 inhibits transforming growth factor-beta-Smad3 signalling." in: Anticancer research, Vol. 24, Issue 3a, pp. 1337-45, 2004 (PubMed).

Zhu, Sun, Xie et al.: "Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells." in: Stroke; a journal of cerebral circulation, Vol. 34, Issue 10, pp. 2483-8, 2003 (PubMed).

Li, Issa, Kumar et al.: "CD105 prevents apoptosis in hypoxic endothelial cells." in: Journal of cell science, Vol. 116, Issue Pt 13, pp. 2677-85, 2003 (PubMed).