Cathepsin K antibody (AA 115-329)

Catalog No. ABIN3022539

Product Details anti-Cathepsin K Antibody

Target: Cathepsin K (CTSK)

Binding Specificity: AA 115-329

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin K antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: APDSVDYRKK GYVTPVKNQG QCGSCWAFSS VGALEGQLKK KTGKLLNLSP QNLVDCVSEN DGCGGGYMTN AFQYVQKNRG IDSEDAYPYV GQEESCMYNP TGKAAKCRGY REIPEGNEKA LKRAVARVGP VSVAIDASLT SFQFYSKGVY YDESCNSDNL NHAVLAVGYG IQKGNKHWII KNSWGENWGN KGYILMARNK NNACGIANLA SFPKM

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 115-329 of human CTSK (NP_000387.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Cathepsin K antibody (ABIN3022539)

Doss, Samarpita, Ganesan, Rasool: "Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-κB signalling pathway." in: Life sciences, Vol. 207, pp. 284-295, (2018) (PubMed).

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: CTSK (CTSK Products)

Synonyms: CTS02 antibody, CTSO antibody, CTSO1 antibody, CTSO2 antibody, PKND antibody, PYCD antibody, AI323530 antibody, MMS10-Q antibody, Ms10q antibody, catK antibody, CTSK antibody, wu:fa95f03 antibody, wu:fb08b05 antibody, zgc:110367 antibody, cts02 antibody, ctso antibody, ctso1 antibody, ctso2 antibody, pknd antibody, pycd antibody, OC-2 antibody, catk antibody, cathepsin K antibody, cathepsin K L homeolog antibody, Cathepsin K antibody, CTSK antibody, Ctsk antibody, ctsk antibody, ctsk.L antibody, catk antibody

Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.,CTSK,CTS02,CTSO,CTSO1,CTSO2,PKND,PYCD,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Extracellular Matrix,Ubiquitin,Neuroscience,Cardiovascular,Angiogenesis,CTSK

Molecular Weight: 36 kDa

Gene ID: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades