Cyclin B1 antibody (C-Term)

Catalog No. ABIN3022807

Product Details anti-Cyclin B1 Antibody

Target: Cyclin B1 (CCNB1)

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: TMLDYDMVHF PPSQIAAGAF CLALKILDNG EWTPTLQHYL SYTEESLLPV MQHLAKNVVM VNQGLTKHMT VKNKYATSKH AKISTLPQLN SALVQDLAKA VAKV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 330 to the C-terminus of human Cyclin B1 (NP_114172.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Cyclin B1 antibody (ABIN3022807)

Dong, Zheng, Wang, Tang, Yan, Zhou, Huang: "A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer." in: European journal of pharmacology, Vol. 828, pp. 67-79, (2018) (PubMed).

Deng, Li, Zhao, Yuan, Li: "Antitumor activity of the microtubule inhibitor MBRI-001 against human hepatocellular carcinoma as monotherapy or in combination with sorafenib." in: Cancer chemotherapy and pharmacology, Vol. 81, Issue 5, pp. 853-862, (2018) (PubMed).

Tsai, Yu, Lin, Cheng, Chen, Pang: "Prevention of Simvastatin-Induced Inhibition of Tendon Cell Proliferation and Cell Cycle Progression by Geranylgeranyl Pyrophosphate." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 149, Issue 2, pp. 326-34, (2016) (PubMed).

Cheng, Yang, Fang, Ma, Gong, Wang, Li, Xu: "Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation." in: Nature communications, Vol. 6, pp. 7023, (2015) (PubMed).

Yu, Pang, Wu, Lin, Tseng, Tsai: "Platelet-rich plasma increases proliferation of tendon cells by modulating Stat3 and p27 to up-regulate expression of cyclins and cyclin-dependent kinases." in: Cell proliferation, Vol. 48, Issue 4, pp. 413-20, (2015) (PubMed).

Target Details for Cyclin B1

Target: Cyclin B1 (CCNB1)

Alternative Name: CCNB1 (CCNB1 Products)

Synonyms: ccnb antibody, cycb antibody, cb267 antibody, cycb1 antibody, wu:fa19g04 antibody, wu:fb16d01 antibody, wu:fb16e07 antibody, wu:fi21c01 antibody, ccnb1 antibody, MGC53596 antibody, CCNB antibody, Ccnb1-rs1 antibody, Ccnb1-rs13 antibody, CycB1 antibody, Cycb-4 antibody, Cycb-5 antibody, Cycb1-rs1 antibody, cyclin B1 antibody, cyclin B1 S homeolog antibody, ccnb1 antibody, ccnb1.2 antibody, ccnb1.S antibody, CCNB1 antibody, Ccnb1 antibody, ccnb1.2.S antibody

Background: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.,CCNB,CCNB1,Cyclin B1,cyclin B1,Epigenetics & Nuclear Signaling,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cyclins,G2/M DNA Damage Checkpoint,Endocrine & Metabolism,AMPK Signaling Pathway,CCNB1

Molecular Weight: 44 kDa/48 kDa

Gene ID: 891

UniProt: P14635

Pathways: Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, M Phase