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GPR37 antibody (Extracellular Domain, N-Term)

GPR37 Reactivity: Human IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN302333
  • Target See all GPR37 Antibodies
    GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))
    Binding Specificity
    • 15
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain, N-Term
    Reactivity
    • 47
    • 28
    • 15
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 46
    • 1
    Rabbit
    Clonality
    • 46
    • 1
    Polyclonal
    Conjugate
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPR37 antibody is un-conjugated
    Application
    • 17
    • 15
    • 13
    • 13
    • 10
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects PAEL Receptor (GPR37).
    Purification
    Immunoaffinity Chromatography
    Immunogen
    GPR37 antibody was raised against synthetic peptide from N-terminal extracellular domain of human GPR37.
    Top Product
    Discover our top product GPR37 Primary Antibody
  • Application Notes
    Immunohistochemistry on paraffin sections (3 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.09 % sodium azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.
  • Target
    GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))
    Abstract
    GPR37 Products
    Synonyms
    ACCA antibody, EDNRBL antibody, PAELR antibody, hET(B)R-LP antibody, AI848630 antibody, Pael-R antibody, Ednrbl antibody, G protein-coupled receptor 3 antibody, G protein-coupled receptor 37 antibody, GPR3 antibody, GPR37 antibody, Gpr37 antibody
    Background
    GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death.Synonyms: ETBR-LP-1, Endothelin B receptor-like protein 1, G-protein coupled receptor 37, PAELR, Parkin-associated endothelin receptor-like receptor
    Gene ID
    2861
    NCBI Accession
    NP_005293
    UniProt
    O15354
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