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CD3 epsilon antibody

CD3E Reactivity: Human, Mouse, Pig, Rat, Rabbit, Cow, Horse, Guinea Pig, Dog, Hamster, Sheep, Chicken, Opossum, Primate, Cat, Cryptomys amatus (Mole rat), Elephant, Frog FACS, WB, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3026772
  • Target See all CD3 epsilon (CD3E) Antibodies
    CD3 epsilon (CD3E)
    Reactivity
    • 218
    • 162
    • 44
    • 42
    • 18
    • 8
    • 8
    • 8
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Human, Mouse, Pig, Rat, Rabbit, Cow, Horse, Guinea Pig, Dog, Hamster, Sheep, Chicken, Opossum, Primate, Cat, Cryptomys amatus (Mole rat), Elephant, Frog
    Host
    • 143
    • 118
    • 33
    • 22
    • 20
    • 8
    • 1
    Rabbit
    Clonality
    • 218
    • 121
    • 6
    Polyclonal
    Conjugate
    • 127
    • 31
    • 27
    • 20
    • 15
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD3 epsilon antibody is un-conjugated
    Application
    • 235
    • 158
    • 86
    • 82
    • 71
    • 70
    • 27
    • 27
    • 25
    • 22
    • 14
    • 14
    • 13
    • 13
    • 8
    • 6
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    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP)
    Characteristics
    This antibody recognizes the epsilon-chain of CD3 (CD3e), which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28 kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the Tcell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the Tcell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the Tcell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the Tcell surface. CD3 antigen is a highly specific marker for Tcells, and is present in majority of Tcell neoplasms.
    Purification
    Protein A purified CD3e antibody
    Immunogen
    Amino acids ERPPPVPNPDYEP (156-168) were used as the immunogen for this CD3e antibody.
    Isotype
    IgG
    Top Product
    Discover our top product CD3E Primary Antibody
  • Application Notes
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD3e antibody to be titered up or down for optimal performance.\. FACS: use the CD3e antibody at 0.5-1 μg/million cells,WB: 0.5-1.0 μg/mL,IP: 1-2 μg/500 μg protein lysate,
    Restrictions
    For Research Use only
  • Concentration
    0.2 mg/mL
    Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store the CD3e antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    CD3 epsilon (CD3E)
    Alternative Name
    CD3e (CD3E Products)
    Synonyms
    cd3e antibody, CD3E antibody, t3e antibody, tcre antibody, AI504783 antibody, CD3 antibody, CD3epsilon antibody, T3e antibody, T3E antibody, TCRE antibody, CD3e molecule antibody, CD3 antigen, epsilon polypeptide antibody, cd3e antibody, CD3E antibody, Cd3e antibody
    Background
    This antibody recognizes the epsilon-chain of CD3 (CD3e), which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28  kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the Tcell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the Tcell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the Tcell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the Tcell surface. CD3 antigen is a highly specific marker for Tcells, and is present in majority of Tcell neoplasms.
    Gene ID
    916
    Pathways
    TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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