PERP antibody

Catalog No. ABIN302849

Product Details anti-PERP Antibody

Target: PERP (TP53 Apoptosis Effector (PERP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PERP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: This antibody reacts to a synthetic peptide corresponding to amino acids near the carboxy terminus of human PERP, which differ from the mouse sequence by three amino acids (7-9).

Purification: DEAE-column chromatography

Immunogen: Synthetic peptide

Application Details

Application Notes: Western Blot: 0,5 - 1 μg/mL. Immunohistochemistry: 5 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline, containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer.

Target Details for PERP

Target: PERP (TP53 Apoptosis Effector (PERP))

Alternative Name: PERP (PERP Products)

Synonyms: KCP1 antibody, KRTCAP1 antibody, PIGPC1 antibody, RP3-496H19.1 antibody, THW antibody, dJ496H19.1 antibody, 1110017A08Rik antibody, kcp1 antibody, krtcap1 antibody, pigpc1 antibody, thw antibody, fk24g11 antibody, wu:fk24g11 antibody, PERP antibody, PERP, TP53 apoptosis effector antibody, PERP, TP53 apoptosis effector S homeolog antibody, PERP antibody, Perp antibody, perp.S antibody, perp antibody

Background: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.Synonyms: KCP-1, KCP1, KRTCAP1, Keratinocyte-associated protein 1, P53-induced protein PIGPC1, PERP, PIGPC1, THW, Transmembrane protein THW, p53 apoptosis effector related to PMP-22

Gene ID: 64065

NCBI Accession: NP_071404

UniProt: Q96FX8

Pathways: Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity